Peptide Modifications intermediate
Peptide Acetylation Sites
Overview of N-terminal and lysine acetylation in peptide stability and function.
By Encyclopeptide Editorial | 1 min read
acetylation post-translational modification
Overview
Acetylation adds acetyl groups to N-termini or lysine residues, modulating protein stability, localization, and interactions.
Types
- N-terminal acetylation: Co-translational, affects ~80% of human proteins
- Lysine acetylation: Reversible, regulated by HATs and HDACs
Biological Significance
Histone acetylation is a key epigenetic mark. HDAC inhibitors are approved cancer therapeutics. N-terminal acetylation affects protein half-life.
References
- Source: ENCP Peptide Database
- Category: Peptide Modifications
Test Your Knowledge
Reinforce what you learned about Peptide Acetylation Sites with interactive quizzes on Wikipept.
Take a Quiz on Wikipept