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Peptide Modifications intermediate

Peptide Acetylation Sites: Comprehensive Peptide Reference

Comprehensive overview of N-terminal and lysine acetylation and its role in peptide stability, functional modulation, and pharmacokinetic optimization in the...

By Encyclopeptide Editorial | 1 min read
acetylation post-translational modification

Overview

Acetylation adds acetyl groups to N-termini or lysine residues, modulating protein stability, localization, and interactions.

Types

  • N-terminal acetylation: Co-translational, affects ~80% of human proteins
  • Lysine acetylation: Reversible, regulated by HATs and HDACs

Biological Significance

Histone acetylation is a key epigenetic mark. HDAC inhibitors are approved cancer therapeutics. N-terminal acetylation affects protein half-life.

References

  • Source: ENCP Peptide Database
  • Category: Peptide Modifications

Chemical Identity

PropertyValue
NamePeptide Acetylation Sites
CategoryPeptide Modifications

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