Amanitin: Oligopeptide Research Reference
Amanitin, a bioactive peptide compound with documented applications in biomedical research, pharmacological studies, and therapeutic development
Overview
Amanitin is a bioactive peptide with well-characterized properties and therapeutic applications. It is derived from Amanita phalloides (Death Cap).
Structure
| Property | Value |
|---|---|
| Name | Amanitin |
| Length | 8 amino acids | | Molecular Weight | 918.97 Da | | Source | Amanita phalloides (Death Cap) | | Category | Fungal Cyclopeptide / Toxin |
Mechanism of Action
Binds to RNA Pol II bridge helix, blocking transcription elongation; prevents mRNA synthesis
Bioactivity
Potent hepatotoxin, lethal at microgram doses
Therapeutic Potential
Antibody-drug conjugates (ADCs) for targeted cancer therapy (e.g., amanitin-conjugated ADCs)
References
- Wikipept Peptide Database
- Primary literature (see individual entries)
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