Amphotericin B: Oligopeptide Research Reference
Amphotericin B, a bioactive peptide compound with documented applications in biomedical research, pharmacological studies, and therapeutic development
Overview
Amphotericin B is a bioactive peptide with well-characterized properties and therapeutic applications. It is derived from Streptomyces nodosus (actinomycete).
Structure
| Property | Value |
|---|---|
| Name | Amphotericin B |
| Length | N/A (macrolide, ~38 atoms in ring) | | Molecular Weight | 924.08 Da | | Source | Streptomyces nodosus (actinomycete) | | Category | Fungal Lipopeptide / Antifungal |
Mechanism of Action
Binds ergosterol forming transmembrane pores; causes K+ leakage, osmotic lysis; also interacts with cholesterol
Bioactivity
Antifungal (broad spectrum, fungicidal), antiparasitic
Therapeutic Potential
Gold standard for invasive fungal infections; liposomal formulations reduce nephrotoxicity
References
- Wikipept Peptide Database
- Primary literature (see individual entries)
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