Angiotensin 1-7
Heptapeptide counter-regulatory hormone of the RAAS that opposes angiotensin II effects through Mas receptor activation.
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C41H62N12O11 |
| Molecular Weight | 899 Da |
| Peptide Class | Heptapeptide Hormone |
| Sequence | DRVYIHP |
| Receptor | Mas receptor |
Structure
Angiotensin 1-7 (Ang 1-7) is a heptapeptide produced from angiotensin I by endopeptidases or from angiotensin II by angiotensin-converting enzyme 2 (ACE2). It is the primary effector of the protective arm of the RAAS, opposing the vasoconstrictive and pro-inflammatory effects of angiotensin II.
Mechanism of Action
Ang 1-7 binds Mas receptors (Mas-related G-protein coupled receptor), activating eNOS and increasing nitric oxide production. This causes vasodilation, anti-fibrotic effects, anti-inflammatory actions, and cardioprotective effects. Ang 1-7 also directly inhibits ACE, reducing Ang II production.
Clinical Applications
- Hypertension: Counter-regulatory to Ang II
- Heart failure: Protective RAAS component
- COVID-19: ACE2/Ang 1-7 axis as therapeutic target
- Fibrosis: Anti-fibrotic effects in heart, lung, kidney
- Diabetes: Improved insulin sensitivity
Pharmacology
- Half-life: 9-10 seconds (rapid metabolism)
- Production: ACE2 cleavage of Ang II (primary)
- Mas receptor: G-protein coupled, eNOS activation
- Balance: Ang II/Ang 1-7 ratio critical in disease
References
- Santos, R.A.S., et al. (2003). Angiotensin 1-7 is an endogenous ligand for the Mas receptor. Proceedings of the National Academy of Sciences, 100, 8258-8263.
- Santos, R.A.S., et al. (2018). Angiotensin 1-7 and the RAAS. Physiological Reviews, 98, 505-553.
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