Antifungal Peptides intermediate
Antifungal Peptide Drugs: Oligopeptide Research Reference
Peptide-based antifungal agents including lipopeptides and cyclic peptides for invasive fungal infections. This peptide or oligopeptide is studied for its bi...
By Encyclopeptide Editorial | 1 min read
antifungal peptide lipopeptide fungal-infection echinocandin
Approved Antifungal Peptides
| Drug | Class | Mechanism | Spectrum |
|---|---|---|---|
| Caspofungin | Echinocandin | Beta-glucan synth | Candida, Aspergillus |
| Micafungin | Echinocandin | Beta-glucan synth | Candida, Aspergillus |
| Anidulafungin | Echinocandin | Beta-glucan synth | Candida |
| Ibrexafungerp | Triterpenoid | Beta-glucan synth | Candida |
Mechanism of Action
Echinocandins inhibit beta-1,3-glucan synthase, preventing synthesis of beta-glucan, a critical component of the fungal cell wall. This mechanism is fungicidal against Candida and fungistatic against Aspergillus.
Clinical Applications
- Invasive candidiasis
- Esophageal candidiasis
- Invasive aspergillosis (salvage therapy)
- Febrile neutropenia
Chemical Identity
| Property | Value |
|---|---|
| Name | Antifungal Peptide Drugs |
| Category | Antifungal Peptides |
References
- Encyclopeptide Database. “Antifungal Peptide Drugs” monograph. encyclopeptide.com.
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