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Bleomycin Glycopeptide Antibiotic
Glycopeptide antitumor antibiotic generating free radicals causing DNA strand breaks, used for Hodgkin lymphoma and germ cell tumors.
By Encyclopeptide Editorial | 1 min read
bleomycin glycopeptide DNA-damage Hodgkin-lymphoma free-radicals
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C55H84N17O21S3 |
| Molecular Weight | 1415.55 g/mol |
| CAS Number | 11056-06-7 |
| Product Name | Blenoxane |
| Source | Streptomyces verticillus |
Structure
Bleomycin is a glycopeptide antibiotic consisting of a metal-binding domain (beta-aminoalanine, beta-hydroxyhistidine, pyrimidinylpropionamide) and a bithiazole tail.
Mechanism
Chelates Fe2+ and reacts with O2 to form reactive oxygen species (superoxide, hydroxyl radicals) that cause single- and double-strand DNA breaks. The bithiazole tail intercalates into DNA.
Clinical Applications
- Hodgkin lymphoma (ABVD regimen)
- Testicular cancer
- Ovarian cancer
- Head and neck cancers
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