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Peptide Interactions intermediate

BNP → Neprilysin (Substrate): Comprehensive Peptide Refer...

BNP as a substrate for neprilysin enzyme, relevant to sacubitril/valsartan heart failure therapy. This peptide or oligopeptide is studied for its biological ...

By Encyclopeptide Editorial | 1 min read
peptide-interactions peptide oligopeptide

Overview

BNP → Neprilysin (Substrate) is a bioactive peptide with well-characterized properties and therapeutic applications.

Mechanism of Action

Neprilysin cleaves BNP at Cys10-Phe11, Met12-Val13, and other sites within the 17-membered disulfide ring, producing inactive fragments. BNP normally acts via NPR-A receptor (GC-A) to generate cGMP, promoting natriuresis and vasodilation.

References

  • Wikipept Peptide Database
  • Primary literature (see individual entries)

Chemical Identity

PropertyValue
NameBNP → Neprilysin (Substrate)
CategoryPeptide Interactions

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