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Cyclic Peptide-Peptoid Hybrids
Chimeric molecules combining cyclic peptide and peptoid elements for enhanced proteolytic stability and cell penetration.
By Encyclopeptide Editorial | 1 min read
cyclic-peptide peptoid hybrid stability cell-penetration
Overview
Cyclic peptide-peptoid hybrids combine the structural diversity of cyclic peptides with the proteolytic resistance of peptoids, creating chimeric molecules with enhanced drug-like properties.
Design Principles
Peptoid Elements
- N-substituted glycines (peptoid monomers)
- Resistance to proteolysis
- Enhanced cell penetration
- Conformational effects
Cyclization Benefits
- Pre-organized conformation
- Enhanced receptor selectivity
- Improved metabolic stability
- Reduced conformational entropy penalty
Therapeutic Applications
- Protein-protein interaction inhibitors
- Antimicrobial peptides
- Enzyme inhibitors
- Receptor modulators
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