Therapeutic Peptides Expanded 2 intermediate
Datopotamab Deruxtecan: Oligopeptide Research Reference
Datopotamab Deruxtecan, a bioactive peptide compound with documented applications in biomedical research, pharmacological studies, and therapeutic development
By Encyclopeptide Editorial | 1 min read
therapeutic-peptides-expanded-2 peptide oligopeptide
Overview
Datopotamab Deruxtecan is a bioactive peptide with well-characterized properties and therapeutic applications.
Structure
| Property | Value |
|---|---|
| Name | Datopotamab Deruxtecan |
| Sequence | Anti-Trop2 monoclonal antibody conjugated to deruxtecan (topoisomerase I inhibitor) via cleavable tetrapeptide linker; DAR ~4 |
| Length | ~1327 amino acids (antibody) + linker-payload |
| Molecular Weight | ~150 kDa (ADC) |
| Category | Oncology / Antibody-Drug Conjugate |
Mechanism of Action
ADC targeting Trop2; delivers DXd payload causing DNA damage. Lower DAR and different linker profile vs. T-DXd
References
- Wikipept Peptide Database
- Primary literature (see individual entries)
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