Depression: Oligopeptide Research Reference
Major depressive disorder (MDD) characterized by persistent depressed mood or anhedonia for ≥2 weeks, plus ≥4 additional symptoms (weight change, sleep distu...
Overview
Major depressive disorder (MDD) characterized by persistent depressed mood or anhedonia for ≥2 weeks, plus ≥4 additional symptoms (weight change, sleep distu…lessness, concentration difficulties, suicidal ideation). Pathophysiology: monoamine hypothesis (serotonin, norepinephrine, dopamine deficits), HPA axis dysregulation, neuroinflammation, neuroplasticity deficits. Treatments: SSRIs (fluoxetine, sertraline), SNRIs (venlafaxine, duloxetine), TCAs, MAOIs, ketamine/esketamine (nasal spray), ECT, TMS.
Clinical Significance
This molecule has important therapeutic or diagnostic applications in clinical medicine.
References
- Encyclopeptide Database. “Depression” monograph. encyclopeptide.com.
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