Therapeutic Peptides advanced
Depsipeptide Chemistry
Chemistry and pharmacology of depsipeptides containing both amide and ester bonds, including natural products and drug candidates.
By Encyclopeptide Editorial | 1 min read
depsipeptide chemistry ester-bond natural-product drug-design
Overview
Depsipeptides are peptides containing one or more ester bonds in addition to amide bonds. This structural feature imparts unique conformational properties and biological activities.
Key Depsipeptide Natural Products
| Compound | Source | Activity |
|---|---|---|
| Romidepsin | Chromobacterium | HDAC inhibition |
| Enniatin | Fusarium | Antifungal |
| Beauvericin | Beauveria | Insecticidal |
| K-13 | Micromonospora | ACE inhibition |
Chemical Properties
- Ester bonds: More susceptible to hydrolysis than amide bonds
- Conformational flexibility: Reduced hydrogen bonding
- Lipophilicity: Generally increased membrane permeability
- Stability: pH and temperature dependent
Chemical Identity
| Property | Value |
|---|---|
| Name | Depsipeptide Chemistry |
| Category | Therapeutic Peptides |
References
- Encyclopeptide Database. “Depsipeptide Chemistry” monograph. encyclopeptide.com.
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