Dolastatin 10: Oligopeptide Research Reference
Dolastatin 10, a bioactive peptide compound with documented applications in biomedical research, pharmacological studies, and therapeutic development
Overview
Dolastatin 10 is a bioactive peptide with well-characterized properties and therapeutic applications. It is derived from Dolabella auricularia (sea hare).
Structure
| Property | Value |
|---|---|
| Name | Dolastatin 10 |
| Length | 5 amino acid residues | | Molecular Weight | 785.0 Da | | Source | Dolabella auricularia (sea hare) | | Category | Marine Anti-Cancer Peptide |
Mechanism of Action
Binds tubulin at vinca domain, inhibits polymerization
Bioactivity
Potent anti-proliferative
Therapeutic Potential
Lead for ADCs (brentuximab vedotin), monotherapy (Phase II)
References
- Wikipept Peptide Database
- Primary literature (see individual entries)
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