Therapeutic Peptides Expanded 2 intermediate
Donanemab: Oligopeptide Research Reference
Donanemab, a bioactive peptide compound with documented applications in biomedical research, pharmacological studies, and therapeutic development
By Encyclopeptide Editorial | 1 min read
therapeutic-peptides-expanded-2 peptide oligopeptide
Overview
Donanemab is a bioactive peptide with well-characterized properties and therapeutic applications.
Structure
| Property | Value |
|---|---|
| Name | Donanemab |
| Sequence | Humanized IgG1 monoclonal antibody targeting pyroglutamate-modified Aβ (N3pG-Aβ) in amyloid plaques |
| Length | ~1330 amino acids |
| Molecular Weight | ~148 kDa |
| Category | Neurology / Anti-Amyloid Antibody |
Mechanism of Action
Binds modified Aβ plaques (pyroglutamate Aβ epitope), inducing rapid plaque clearance via microglial phagocytosis; plaque clearance allows for time-limited treatment
References
- Wikipept Peptide Database
- Primary literature (see individual entries)
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