GLP-1 Family intermediate
Dulaglutide Fc Fusion Technology
Once-weekly GLP-1 receptor agonist using human IgG4 Fc domain fusion for extended half-life through FcRn-mediated recycling.
By Encyclopeptide Editorial | 1 min read
dulaglutide GLP-1 Fc-fusion once-weekly diabetes
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C2544H3900N686O784S18 |
| Molecular Weight | ~63 kDa |
| CAS Number | 923950-08-7 |
| Product Name | Trulicity |
| Peptide Class | GLP-1/Fc Fusion Protein |
Structure
Dulaglutide covalently links two GLP-1(7-37) analog molecules to a human IgG4 Fc domain via flexible linkers. The large molecular size reduces renal clearance while FcRn binding enables endosomal recycling.
Pharmacokinetics
- Half-life: ~5 days
- Dosing: Once weekly subcutaneous
- Bioavailability: 65%
Biological Significance
This molecule plays important roles in biological systems and has potential therapeutic applications.
References
- Encyclopeptide Database. “Dulaglutide Fc Fusion Technology” monograph. encyclopeptide.com.
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