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Eribulin Mesylate
Synthetic halichondrin B analog microtubule dynamics inhibitor for metastatic breast cancer and liposarcoma.
By Encyclopeptide Editorial | 1 min read
eribulin halichondrin microtubule breast-cancer sarcoma
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C32H43NO11 |
| Molecular Weight | 623.68 g/mol |
| CAS Number | 253128-41-5 |
| Product Name | Halaven |
| Source | Synthetic analog of halichondrin B |
Structure
Eribulin is a simplified macrocyclic ketone analog of the marine natural product halichondrin B. It retains the critical C1-C26 macrocyclic portion responsible for microtubule binding.
Mechanism
Inhibits microtubule dynamics by binding to the plus end of microtubules, suppressing microtubule polymerization without affecting depolymerization. This unique mechanism leads to mitotic arrest and apoptosis.
Clinical Applications
- Metastatic breast cancer (after 2+ prior chemotherapies)
- Unresectable or metastatic liposarcoma
References
- Encyclopeptide Database. “Eribulin Mesylate” monograph. encyclopeptide.com.
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