Amphibian Peptides intermediate
Esculentin-1: Antimicrobial Peptide Reference
Esculentin-1, a bioactive peptide compound with documented applications in biomedical research, pharmacological studies, and therapeutic development
By Encyclopeptide Editorial | 1 min read
amphibian-peptides peptide oligopeptide
Overview
Esculentin-1 is a bioactive peptide with well-characterized properties and therapeutic applications. It is derived from Rana esculenta (European green frog).
Structure
| Property | Value |
|---|---|
| Name | Esculentin-1 |
| Sequence | GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC |
| Length | 46 amino acids |
| Molecular Weight | 4863.6 Da |
| Source | Rana esculenta (European green frog) |
| Category | Amphibian Antimicrobial |
Mechanism of Action
Large antimicrobial peptide with C-terminal disulfide loop, membrane permeabilization and LPS binding
Bioactivity
Very potent antimicrobial, particularly against Pseudomonas aeruginosa
Therapeutic Potential
Anti-pseudomonal therapeutics, cystic fibrosis treatment
References
- Wikipept Peptide Database
- Primary literature (see individual entries)
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