Peptide Modifications advanced
Ester Bonds in Peptides
Overview of ester bonds in depsipeptides and their role in cyclic peptide design.
By Encyclopeptide Editorial | 1 min read
ester depsipeptide cyclic modification
Overview
Ester bonds in depsipeptides replace amide bonds, creating hybrid peptide-ester structures with distinct properties.
Types
- Depsipeptides: Mixed amide-ester cyclic peptides
- Lactones: Intramolecular ester bonds in cyclodepsipeptides
- Polyketide-peptide hybrids: Natural product scaffolds
Biological Significance
Depsipeptides include anticancer natural products (romidepsin, HDAC inhibitor) and ionophorous antibiotics (enniatin).
References
- Source: ENCP Peptide Database
- Category: Peptide Modifications
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