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Ester Bonds in Peptides: Post-Translational Modification ...

Overview of ester bonds in depsipeptides and their role in cyclic peptide design. This modification affects peptide stability, receptor binding, and biologic...

By Encyclopeptide Editorial | 1 min read
ester depsipeptide cyclic modification

Overview

Ester bonds in depsipeptides replace amide bonds, creating hybrid peptide-ester structures with distinct properties.

Types

  • Depsipeptides: Mixed amide-ester cyclic peptides
  • Lactones: Intramolecular ester bonds in cyclodepsipeptides
  • Polyketide-peptide hybrids: Natural product scaffolds

Biological Significance

Depsipeptides include anticancer natural products (romidepsin, HDAC inhibitor) and ionophorous antibiotics (enniatin).

References

  • Source: ENCP Peptide Database
  • Category: Peptide Modifications

Chemical Identity

PropertyValue
NameEster Bonds in Peptides
CategoryPeptide Modifications

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