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GLP-1 Family advanced

GLP-1 and Exendin-4 Receptor Cross-Reactivity

Comparison of native GLP-1 and Gila monster exendin-4 at the GLP-1 receptor including binding differences.

By Encyclopeptide Editorial | 1 min read
GLP-1 exendin-4 cross-reactivity receptor comparative

Sequence Comparison

GLP-1(7-36):    HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Exendin-4:      HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGP
                **  **** *  **   ** **  ***

Pharmacological Implications

  1. DPP-4 resistance: Exendin-4 has Gly at position 2
  2. Half-life: Exendin-4 slightly longer than native GLP-1
  3. Both activate GLP-1R but not GIPR or glucagon receptor

Chemical Identity

PropertyValue
NameGLP-1 and Exendin-4 Receptor Cross-Reactivity
CategoryGLP-1 Family

Biological Significance

This molecule plays important roles in biological systems and has potential therapeutic applications.

References

  1. Encyclopeptide Database. “GLP-1 and Exendin-4 Receptor Cross-Reactivity” monograph. encyclopeptide.com.

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