GLP-1 Family advanced
GLP-1 Fatty Acid Conjugation Strategies
Chemical conjugation of fatty acid moieties to GLP-1 peptides for albumin binding and half-life extension.
By Encyclopeptide Editorial | 1 min read
GLP-1 fatty-acid conjugation albumin-binding half-life
Fatty Acid Conjugation Comparison
| Agent | Fatty Acid | Linker | Half-Life |
|---|---|---|---|
| Liraglutide | C-16 (palmitate) | Glu spacer | 13 hours |
| Semaglutide | C-18 diacid | miniPEG-OEG spacer | ~7 days |
| Tirzepatide | C-20 diacid | Glu-Glu-Glu spacer | ~5 days |
Structure-Activity Relationships
- C-14: Insufficient albumin binding
- C-16: Moderate binding (liraglutide)
- C-18: Strong binding (semaglutide)
- C-20: Very strong binding (tirzepatide)
Chemical Identity
| Property | Value |
|---|---|
| Name | GLP-1 Fatty Acid Conjugation Strategies |
| Category | GLP-1 Family |
Biological Significance
This molecule plays important roles in biological systems and has potential therapeutic applications.
References
- Encyclopeptide Database. “GLP-1 Fatty Acid Conjugation Strategies” monograph. encyclopeptide.com.
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