Peptide Modifications advanced
GPI Anchors on Peptides
Guide to glycosylphosphatidylinositol anchors linking peptides to cell membranes.
By Encyclopeptide Editorial | 1 min read
gpi-anchor membrane lipid modification
Overview
GPI anchors are glycolipid modifications attaching proteins to the outer leaflet of cell membranes.
Structure
The conserved core structure is ethanolamine-PO4-Man-Man-Man-GlcN-acyl-PI, with variable side chains.
Biological Significance
GPI-anchored proteins include CD59, alkaline phosphatase, and prion protein. GPI anchor deficiency causes paroxysmal nocturnal hemoglobinuria.
References
- Source: ENCP Peptide Database
- Category: Peptide Modifications
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