Peptide History intermediate
History of Peptide Drug Delivery
The evolution of peptide delivery from injections to oral, nasal, and transdermal systems.
By Encyclopeptide Editorial | 1 min read
delivery formulation injection history
Overview
Peptide drug delivery has evolved from simple subcutaneous injections to sophisticated oral, nasal, and implantable systems.
Key Milestones
- 1920s: Subcutaneous insulin injections
- 1970s: Nasal peptide delivery explored
- 1980s: Implantable peptide pumps
- 1990s: PEGylation extends half-life
- 2000s: Oral peptide delivery attempts
- 2010s: Microneedle and nanoneedle systems
- 2019: Oral semaglutide (Rybelsus) approved
Impact
Overcoming the delivery challenge remains the greatest obstacle to broader peptide therapeutic use. Oral semaglutide marked a breakthrough for oral peptides.
References
- Source: ENCP Peptide Database
- Category: Peptide History
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