Peptide History intermediate
History of Peptide Formulation Science
The development of formulation strategies for peptide stability and delivery.
By Encyclopeptide Editorial | 1 min read
formulation stability delivery history
Overview
Peptide formulation science has evolved to address the unique stability and delivery challenges of peptide therapeutics.
Key Developments
- 1920s: Simple aqueous insulin formulations
- 1950s: Protamine zinc insulin for extended action
- 1970s: Lyophilized peptide formulations
- 1980s: Depot injectable formulations
- 1990s: PEGylation for half-life extension
- 2000s: Nanoparticle and liposomal formulations
- 2010s: Oral permeation enhancer technology
Impact
Formulation innovation has been as important as molecular design in enabling successful peptide therapeutics.
References
- Source: ENCP Peptide Database
- Category: Peptide History
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