Peptide History advanced
History of X-ray Crystallography
How X-ray crystallography enabled atomic-resolution peptide and protein structure determination.
By Encyclopeptide Editorial | 1 min read
crystallography x-ray structure history
Overview
X-ray crystallography has provided the majority of atomic-resolution structures for peptides and proteins since the early 20th century.
Key Milestones
- 1895: Wilhelm Rontgen discovers X-rays
- 1912: Max von Laue demonstrates X-ray diffraction
- 1953: Watson and Crick determine DNA structure
- 1958: Kendrew determines myoglobin structure
- 1960: Perutz determines hemoglobin structure
- 1962: Nobel Prize to Kendrew and Perutz
- 2000s: Synchrotron radiation advances
Impact
X-ray crystallography remains the gold standard for high-resolution peptide and protein structures, essential for drug design and mechanistic studies.
References
- Source: ENCP Peptide Database
- Category: Peptide History
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