Insulin Family advanced
Insulin A-Chain Mutants
Engineered insulin A-chain variants with altered receptor binding affinity used in structure-activity studies.
By Encyclopeptide Editorial | 1 min read
insulin A-chain mutants structure-activity engineering
Key Mutants
- GlyA1->Ser: Reduced receptor affinity by 200-fold
- IleA2->Val: Modest reduction in binding
- ValA3->Asp: Abolished receptor binding
- GluA4->Gln: Altered receptor selectivity
- ThrA8->Asp: Reduced biological activity
Research Applications
These mutants serve as tools for understanding insulin-receptor interactions and for engineering novel insulin analogues with modified receptor selectivity profiles.
Chemical Identity
| Property | Value |
|---|---|
| Name | Insulin A-Chain Mutants |
| Category | Insulin Family |
Biological Significance
This molecule plays important roles in biological systems and has potential therapeutic applications.
References
- Encyclopeptide Database. “Insulin A-Chain Mutants” monograph. encyclopeptide.com.
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