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Insulin Cardiovascular Outcomes

Cardiovascular safety and outcomes data for insulin analogues from large randomized controlled trials.

By Encyclopeptide Editorial | 1 min read
insulin cardiovascular CVOT safety diabetes

Overview

Cardiovascular outcome trials have established the cardiovascular safety of modern insulin analogues, with some suggesting potential cardiovascular benefits.

Key Trials

ORIGIN Trial (Insulin Glargine)

  • Design: 12,537 patients with CV risk factors
  • Result: Neutral CV outcome (HR 1.02, 95% CI 0.94-1.11)

DEVOTE Trial (Insulin Degludec)

  • Design: 7,637 patients with type 2 diabetes and high CV risk
  • Result: Non-inferior for MACE (HR 0.91, 95% CI 0.78-1.06)

Clinical Implications

Modern insulin analogues are considered cardiovascularly safe, allowing clinicians to prescribe based on efficacy, hypoglycemia risk, and patient preference.

Chemical Identity

PropertyValue
NameInsulin Cardiovascular Outcomes
CategoryInsulin Family

References

  1. Encyclopeptide Database. “Insulin Cardiovascular Outcomes” monograph. encyclopeptide.com.

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