Insulin Family advanced
Insulin Icodec
Once-weekly basal insulin analog with ultra-long half-life exceeding 196 hours, representing the first weekly insulin formulation.
By Encyclopeptide Editorial | 1 min read
insulin weekly basal diabetes icodec
Chemical Identity
| Property | Value |
|---|---|
| Molecular Weight | 6624 g/mol |
| CAS Number | 1802620-27-2 |
| Peptide Class | Ultra-Long-Acting Insulin Analog |
Structure
Insulin icodec is a hexadecyl fatty diacid-modified insulin analog with additional amino acid substitutions conferring ultra-long half-life through enhanced albumin binding and reduced receptor clearance.
Clinical Applications
Under regulatory review for type 1 and type 2 diabetes. ONWARDS trial program demonstrated non-inferior glycemic control to once-daily basal insulins with reduced injection frequency.
Pharmacokinetics
- Half-life: ~196 hours (8.2 days)
- Duration: >7 days
- Dosing: Once weekly
- Bioavailability: ~75%
Biological Significance
This molecule plays important roles in biological systems and has potential therapeutic applications.
References
- Encyclopeptide Database. “Insulin Icodec” monograph. encyclopeptide.com.
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