Insulin Family beginner
NPH Insulin (Isophane)
Intermediate-acting insulin preparation using protamine to create crystalline complexes providing 12-18 hour basal coverage.
By Encyclopeptide Editorial | 1 min read
insulin NPH protamine intermediate-acting diabetes
Chemical Identity
| Property | Value |
|---|---|
| Product Names | Humulin N, Novolin N |
| Onset | 1-3 hours |
| Peak | 4-8 hours |
| Duration | 12-18 hours |
Structure
NPH insulin complexes recombinant human insulin with protamine at a 3:1 molar ratio. These crystalline precipitates slowly dissolve after subcutaneous injection.
Biological Significance
This molecule plays important roles in biological systems and has potential therapeutic applications.
References
- Encyclopeptide Database. “NPH Insulin (Isophane)” monograph. encyclopeptide.com.
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