Insulin Family advanced
PEGylated Insulin Analogues: Comprehensive Peptide Reference
Polyethylene glycol conjugation of insulin for half-life extension through increased hydrodynamic radius. This peptide or oligopeptide is studied for its bio...
By Encyclopeptide Editorial | 1 min read
insulin PEG PEGylation half-life diabetes
Overview
PEGylation attaches polyethylene glycol chains to insulin, dramatically increasing hydrodynamic radius and reducing renal clearance. This approach extends half-life while maintaining bioactivity.
Key Features
- Half-life extension: 10-100x depending on PEG size
- Mechanism: Reduced glomerular filtration
- Trade-off: Potential reduced receptor binding
- Applications: Ultra-long-acting basal insulins
Challenges
- Site-specific PEGylation required
- PEG size optimization
- Maintaining receptor binding affinity
- Immunogenicity considerations
Chemical Identity
| Property | Value |
|---|---|
| Name | PEGylated Insulin Analogues |
| Category | Insulin Family |
References
- Encyclopeptide Database. “PEGylated Insulin Analogues” monograph. encyclopeptide.com.
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