Insulin Family beginner
Premixed Insulin 50/50
Equal-ratio premixed insulin containing 50% intermediate-acting protamine lispro and 50% rapid-acting insulin lispro.
By Encyclopeptide Editorial | 1 min read
insulin premixed lispro biphasic diabetes
Chemical Identity
| Property | Value |
|---|---|
| Product Name | Humalog Mix 50/50 |
| Components | 50% protamine lispro + 50% insulin lispro |
| Route | Subcutaneous |
| Onset | 15 minutes |
Structure
The 50/50 ratio provides a more prandial-dominant profile compared to 75/25, suitable for patients with significant postprandial hyperglycemia.
Clinical Applications
Used in type 2 diabetes with prominent postprandial glucose excursions. Typically dosed twice daily with major meals.
Pharmacokinetics
- Onset: 15 minutes
- Peak: 0.5-1 hour (lispro), 4-8 hours (protamine)
- Duration: 12-16 hours
Biological Significance
This molecule plays important roles in biological systems and has potential therapeutic applications.
References
- Encyclopeptide Database. “Premixed Insulin 50/50” monograph. encyclopeptide.com.
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