Insulin Family beginner
Premixed Insulin 75/25
Fixed-ratio premixed insulin containing 75% intermediate-acting protamine lispro and 25% rapid-acting insulin lispro.
By Encyclopeptide Editorial | 1 min read
insulin premixed lispro protamine diabetes
Chemical Identity
| Property | Value |
|---|---|
| Product Name | Humalog Mix 75/25 |
| Components | 75% protamine lispro + 25% insulin lispro |
| Route | Subcutaneous |
| Onset | 15-30 minutes |
Structure
Premixed 75/25 combines two physically distinct insulin species: protamine lispro crystalline precipitate for intermediate coverage and free insulin lispro for prandial control.
Clinical Applications
Indicated for type 1 and type 2 diabetes requiring both basal and prandial insulin. Provides convenient twice-daily dosing with meals.
Pharmacokinetics
- Onset: 15-30 minutes
- Peak 1 (lispro): 0.5-1.5 hours
- Peak 2 (protamine): 4-8 hours
- Duration: 12-18 hours
Test Your Knowledge
Reinforce what you learned about Premixed Insulin 75/25 with interactive quizzes on Wikipept.
Take a Quiz on Wikipept