Skip to content
Peptide Modifications advanced

Isopeptide Bonds in Peptides: Comprehensive Peptide Refer...

Learn about non-canonical isopeptide bonds in peptide cross-linking and stability. This modification affects peptide stability, receptor binding, and biologi...

By Encyclopeptide Editorial | 1 min read
isopeptide cross-linking stability modification

Overview

Isopeptide bonds are non-canonical amide bonds between amino acid side chains, not involving the main chain.

Types

  • Lys-Asn/Gln: Found in bacterial surface proteins
  • Ubiquitin K48/K63: Protein degradation signals
  • Transglutaminase-catalyzed: Lys-Gln cross-links

Biological Significance

Isopeptide bonds in bacterial pili provide extreme mechanical stability. Engineered isopeptide bonds create stable protein fusions (SpyTag/SpyCatcher).

References

  • Source: ENCP Peptide Database
  • Category: Peptide Modifications

Chemical Identity

PropertyValue
NameIsopeptide Bonds in Peptides
CategoryPeptide Modifications

Test Your Knowledge

Reinforce what you learned about Isopeptide Bonds in Peptides: Comprehensive Peptide Refer... with interactive quizzes on Wikipept.

Take a Quiz on Wikipept