Therapeutic Peptides Expanded 2 intermediate
Nusinersen: Oligopeptide Research Reference
Nusinersen, a bioactive peptide compound with documented applications in biomedical research, pharmacological studies, and therapeutic development
By Encyclopeptide Editorial | 1 min read
therapeutic-peptides-expanded-2 peptide oligopeptide
Overview
Nusinersen is a bioactive peptide with well-characterized properties and therapeutic applications.
Structure
| Property | Value |
|---|---|
| Name | Nusinersen |
| Sequence | 2′-O-(2-methoxyethyl) phosphorothioate antisense oligonucleotide (18-mer) |
| Length | 18 nucleotides (2′-MOE chemistry) |
| Molecular Weight | ~7.1 kDa (sodium salt) |
| Category | Rare Disease / Antisense Oligonucleotide |
Mechanism of Action
Antisense oligonucleotide binds ISS-N1 (intronic splicing silencer) in SMN2 pre-mRNA, promoting inclusion of exon 7 in mature mRNA, thereby increasing full-length SMN protein production
References
- Wikipept Peptide Database
- Primary literature (see individual entries)
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