Omiganan
Synthetic indolicidin-derived antimicrobial peptide under investigation for catheter-related infections and acne vulgaris.
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C67H115N25O13 |
| Molecular Weight | 1526.8 Da |
| CAS Number | 157354-45-1 |
| Peptide Class | Synthetic Antimicrobial Peptide |
| Sequence | ILRWPWWPWRRK-NH2 |
Structure
Omiganan (MBI-226, CLS001) is a synthetic 12-amino acid cationic peptide derived from indolicidin, a bovine neutrophil antimicrobial peptide. It contains five tryptophan residues providing membrane-binding capacity and three arginine/lysine residues for cationic charge. The peptide adopts a wedge-shaped conformation when bound to membranes.
Mechanism of Action
Omiganan disrupts bacterial and fungal membranes through insertion of tryptophan residues into the lipid bilayer, with cationic residues neutralizing anionic phospholipids. The high tryptophan content enables deep membrane penetration. It also has anti-inflammatory properties through modulation of TLR signaling.
Clinical Applications
- Catheter-related infections: Topical application to prevent CLABSI (Phase III)
- Acne vulgaris: Topical gel for moderate acne (Phase III)
- Rosacea: Anti-inflammatory and antimicrobial effects
- Dermatological infections: Broad-spectrum topical agent
Pharmacokinetics
- Route: Topical only
- Systemic absorption: Negligible
- Spectrum: Gram-positive (including MRSA), gram-negative, fungi
- Concentration: 1-2.5% topical formulation
Safety and Side Effects
Local erythema, pruritus, and mild burning. No systemic adverse effects reported. Well-tolerated in Phase II/III trials.
References
- Rubinchik, E., et al. (2009). In vitro activity of omiganan. Antimicrobial Agents and Chemotherapy, 53, 2924-2927.
- Rubinchik, E., et al. (2009). Omiga
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