Therapeutic Peptides advanced
Pasireotide Somatostatin Analog
Multi-receptor targeted somatostatin analog with high affinity for somatostatin receptor subtype 5 for Cushing's disease.
By Encyclopeptide Editorial | 1 min read
pasireotide somatostatin Cushing SSTR5 endocrine
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C58H66N10O9 |
| Molecular Weight | 1031.2 Da |
| CAS Number | 396091-73-9 |
| Product Name | Signifor |
| Receptor Profile | SSTR5 > SSTR2 > SSTR3 > SSTR1 |
Structure
Pasireotide is a cyclohexapeptide somatostatin analog with a broad receptor binding profile. It has 30-fold higher affinity for SSTR5 compared to octreotide.
Clinical Applications
- Cushing’s disease: FDA-approved (Signifor)
- Acromegaly: Off-label when octreotide/lanreotide fail
- Neuroendocrine tumors: Investigational
Safety Considerations
- Hyperglycemia (common, 72%)
- Requires glucose monitoring
- May worsen diabetes control
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