Peptide Applications intermediate
Peptide Antifungals
Guide to antifungal peptides targeting fungal membranes for treatment of invasive mycoses.
By Encyclopeptide Editorial | 1 min read
antifungal infection membrane application
Overview
Antifungal peptides target fungal cell membranes containing ergosterol, offering novel approaches to treat invasive mycoses.
Types
- Histatin derivatives: Salivary antifungal peptides
- Cecropin-melittin hybrids: Engineered antifungal AMPs
- Lactoferricin: Iron-binding protein derivative
- Cyclotides: Plant-derived cyclic peptides
Mechanism
Antifungal peptides disrupt ergosterol-containing membranes, inhibit cell wall synthesis, or interfere with fungal metabolism.
Clinical Significance
With rising azole resistance, peptide antifungals offer complementary approaches to treat resistant Candida and Aspergillus infections.
References
- Source: ENCP Peptide Database
- Category: Peptide Applications
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