Drug Conjugates advanced
Peptide-Drug Conjugate Technology
Antibody-peptide conjugate and small molecule-peptide conjugate technologies for targeted drug delivery.
By Encyclopeptide Editorial | 1 min read
peptide-drug-conjugate PDC targeted-delivery linker payload
Overview
Peptide-drug conjugates (PDCs) link cytotoxic payloads to targeting peptides through chemical linkers, enabling selective drug delivery to disease tissues.
Conjugate Components
Targeting Peptide
- Receptor-specific ligand
- Cell-penetrating peptide
- Tumor-homing peptide (RGD, NGR, etc.)
Linker Chemistry
- Cleavable (protease-sensitive, pH-sensitive)
- Non-cleavable (thioether, amide)
- Release kinetics optimization
Cytotoxic Payload
- Maytansinoids (DM1, DM4)
- Auristatins (MMAE, MMAF)
- Camptothecin derivatives
- PBD dimers
Clinical Examples
| PDC | Target | Payload | Indication |
|---|---|---|---|
| Lutetium-177 PSMA | PSMA | Radiation | Prostate cancer |
| 177Lu-DOTATATE | SSTR | Radiation | NET |
Test Your Knowledge
Reinforce what you learned about Peptide-Drug Conjugate Technology with interactive quizzes on Wikipept.
Take a Quiz on Wikipept