Formulation Development intermediate
Peptide Drug Excipient Compatibility
Studies assessing the compatibility of peptide active ingredients with pharmaceutical excipients.
By Encyclopeptide Editorial | 1 min read
excipient compatibility formulation stability interaction
Overview
Excipient compatibility studies identify potential interactions between peptide active ingredients and excipients.
Common Excipients
Bulking Agents
- Mannitol, Sucrose, Trehalose, Lactose
Buffers
- Phosphate, Acetate, Histidine, Citrate
Surfactants
- Polysorbate 80, Polysorbate 20, Poloxamer 188
Preservatives
- m-Cresol, Phenol, Benzyl alcohol
Common Incompatibilities
- Reducing sugars (Maillard reaction)
- Oxidizing agents
- Heavy metals
- Aldehyde-containing excipients
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