Drug Delivery advanced
Peptide-Exosome Therapeutics
Exosome-based delivery of therapeutic peptides using natural extracellular vesicles as biocompatible carriers.
By Encyclopeptide Editorial | 1 min read
exosome extracellular-vesicle delivery biocompatible nanoparticle
Overview
Exosomes are natural extracellular vesicles (30-150 nm) that can be engineered to carry therapeutic peptides, offering inherent biocompatibility and the ability to cross biological barriers.
Exosome Engineering
Passive Loading
- Incubation with peptide solutions
- Simple but low efficiency
- Non-destructive
Active Loading
- Electroporation
- Sonication
- Transfection of parent cells
- Higher efficiency
Surface Display
- Genetic fusion to exosome proteins
- Chemical conjugation
- Targeting ligand incorporation
Advantages
- Natural biocompatibility
- Ability to cross blood-brain barrier
- Low immunogenicity
- Protection from degradation
- Cell-specific targeting
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