Peptide Modifications intermediate
Peptidomimetics
Overview of peptidomimetic compounds designed to overcome peptide drug limitations.
By Encyclopeptide Editorial | 1 min read
peptidomimetics drug-design bioavailability modification
Overview
Peptidomimetics are compounds that mimic peptide structure and function while exhibiting drug-like properties.
Design Strategies
- Backbone modification: N-methylation, retro-inverso
- Side chain constraint: Stapled peptides, bicyclic scaffolds
- Isostere replacement: Amide bond surrogates
- Macrocyclization: Enhanced selectivity and stability
Applications
Successful peptidomimetics include HIV protease inhibitors (saquinavir), ACE inhibitors, and stapled peptides targeting intracellular PPIs.
References
- Source: ENCP Peptide Database
- Category: Peptide Modifications
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