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Peptide Modifications intermediate

Peptidomimetics: Post-Translational Modification Reference

Overview of peptidomimetic compounds designed to overcome peptide drug limitations. This modification affects peptide stability, receptor binding, and biolog...

By Encyclopeptide Editorial | 1 min read
peptidomimetics drug-design bioavailability modification

Overview

Peptidomimetics are compounds that mimic peptide structure and function while exhibiting drug-like properties.

Design Strategies

  • Backbone modification: N-methylation, retro-inverso
  • Side chain constraint: Stapled peptides, bicyclic scaffolds
  • Isostere replacement: Amide bond surrogates
  • Macrocyclization: Enhanced selectivity and stability

Applications

Successful peptidomimetics include HIV protease inhibitors (saquinavir), ACE inhibitors, and stapled peptides targeting intracellular PPIs.

References

  • Source: ENCP Peptide Database
  • Category: Peptide Modifications

Chemical Identity

PropertyValue
NamePeptidomimetics
CategoryPeptide Modifications

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