Anticancer Peptides advanced
Plitidepsin T-Cell Lymphoma Agent
Depsipeptide from marine tunicate Aplidium albicans for relapsed/refractory T-cell lymphoma through translation inhibition.
By Encyclopeptide Editorial | 1 min read
plitidepsin depsipeptide T-cell-lymphoma marine translation
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C33H46N4O4 |
| Molecular Weight | 572.73 g/mol |
| CAS Number | 149607-26-3 |
| Product Name | Aplidin (withdrawn in some markets) |
| Source | Aplidium albicans (marine tunicate) |
Structure
Plitidepsin is a cyclic depsipeptide containing unusual amino acids including dolavaline, dihydroxyisovaline, and a proline derivative.
Mechanism
Binds to eukaryotic elongation factor 1A (eEF1A2), inhibiting protein synthesis and inducing apoptosis through mitochondrial-dependent pathways.
Clinical Applications
- Relapsed/refractory T-cell lymphoma (approved in EU)
- Investigated in multiple myeloma
- COVID-19 investigation (antiviral activity)
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