Anticancer Peptides advanced
Romidepsin HDAC Inhibitor
Cyclic depsipeptide histone deacetylase inhibitor for cutaneous T-cell lymphoma derived from Chromobacterium violaceum.
By Encyclopeptide Editorial | 1 min read
romidepsin HDAC depsipeptide T-cell-lymphoma epigenetic
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C24H36N2O6S2 |
| Molecular Weight | 540.69 g/mol |
| CAS Number | 128564-36-3 |
| Product Name | Istodax |
| Source | Chromobacterium violaceum |
Structure
Romidepsin is a bicyclic depsipeptide containing a disulfide bridge that is reduced intracellularly to reveal two thiol groups that chelate zinc in the HDAC active site.
Mechanism
Inhibits class I HDACs (HDAC1, HDAC2, HDAC4, HDAC6) by chelating the catalytic zinc ion, leading to histone hyperacetylation, chromatin remodeling, and gene reactivation.
Clinical Applications
- Cutaneous T-cell lymphoma (CTCL)
- Peripheral T-cell lymphoma (PTCL)
References
- Encyclopeptide Database. “Romidepsin HDAC Inhibitor” monograph. encyclopeptide.com.
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