**Sequence:** 32-aa mature hormone (proBNP 108 → NT-proBNP 76 + BNP 32)
**Sequence:** 76 amino acids (inactive cleavage product)
Overview
Sequence: 32-aa mature hormone (proBNP 108 → NT-proBNP 76 + BNP 32) is a peptide compound with applications in research and therapeutics. Sequence: 76 amino acids (inactive cleavage product)
Chemical Identity
| Property | Value |
|---|---|
| Name | Sequence: 32-aa mature hormone (proBNP 108 → NT-proBNP 76 + BNP 32) |
| Sequence | Disease: Heart failure; acute coronary syndrome |
Clinical Use: Diagnosis and severity assessment of heart failure; guides therapy (sacubitril/valsartan); prognostic marker
Cutoff Values: <100 pg/mL (acute HF unlikely); 100–400 pg/mL (gray zone); >400 pg/mL (acute HF likely). Age-adjusted: >50 yrs >450; >75 yrs >900 pg/mL (NT-proBNP).
Secreted by ventricular cardiomyocytes in response to wall stretch. Active hormone with vasodilatory, natriuretic, and diuretic effects. Half-life ~20 min.
NT-proBNP (N-Terminal Pro-BNP)
ID: BIO-002 | | Length | 563 amino acids |
| Category | Biomarker Peptides |
Structure
Sequence: 32-aa mature hormone (proBNP 108 → NT-proBNP 76 + BNP 32) belongs to the Biomarker Peptides class of peptides. Its structure and properties make it suitable for various research and therapeutic applications.
Applications
Sequence: 32-aa mature hormone (proBNP 108 → NT-proBNP 76 + BNP 32) has been studied for its potential applications in:
- Biomedical research
- Drug discovery
- Diagnostic applications
- Therapeutic development
References
- Source: biomarker-peptides.md
- Database: Wikipept Peptide Database
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