**Sequence:** 441 amino acids (longest CNS isoform); multiple phosphorylation sites (Thr181, Thr217, Thr231, Ser181, Ser396)

Overview

Sequence: 441 amino acids (longest CNS isoform); multiple phosphorylation sites (Thr181, Thr217, Thr231, Ser181, Ser396) is a peptide compound with applications in research and therapeutics. Sequence: 209 amino acids (PrP^C, normal cellular form); 208 amino acids after signal peptide cleavage

Chemical Identity

Property	Value
Name	Sequence: 441 amino acids (longest CNS isoform); multiple phosphorylation sites (Thr181, Thr217, Thr231, Ser181, Ser396)
Sequence	Disease: Alzheimer’s disease; frontotemporal dementia; traumatic brain injury (CTE)

Clinical Use: CSF p-tau for AD diagnosis (ATN staging); blood-based p-tau217 for screening; prediction of progression from MCI to AD; clinical trial enrichment

Cutoff Values: CSF p-tau181: >20–30 pg/mL (assay-dependent). Plasma p-tau217: >0.25 pg/mL (Lumipulse) or ratio-based cutoffs. p-tau217: highest single-marker accuracy for amyloid and tau PET positivity.

Phosphorylated tau reflects tangle pathology. p-tau217 shows highest accuracy among blood biomarkers for both amyloid and tau PET positivity. p-tau181 most widely validated CSF marker. p-tau231 shows earliest changes in preclinical AD.

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Prion Protein (PrP)

ID: BIO-010 | | Length | 744 amino acids |

| Category | Biomarker Peptides |

Structure

Sequence: 441 amino acids (longest CNS isoform); multiple phosphorylation sites (Thr181, Thr217, Thr231, Ser181, Ser396) belongs to the Biomarker Peptides class of peptides. Its structure and properties make it suitable for various research and therapeutic applications.

Applications

Sequence: 441 amino acids (longest CNS isoform); multiple phosphorylation sites (Thr181, Thr217, Thr231, Ser181, Ser396) has been studied for its potential applications in:

• Biomedical research
• Drug discovery
• Diagnostic applications
• Therapeutic development

References

• Source: biomarker-peptides.md
• Database: Wikipept Peptide Database