**Sequence:** DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (42 residues)
**Sequence:** 140 amino acids (native unfolded)
Overview
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (42 residues) is a peptide compound with applications in research and therapeutics. Sequence: 140 amino acids (native unfolded)
Chemical Identity
| Property | Value |
|---|---|
| Name | Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (42 residues) |
| Sequence | Disease: Alzheimer’s disease (AD); cerebral amyloid angiopathy |
Clinical Use: CSF biomarker for AD diagnosis (ATN classification); amyloid PET correlation; clinical trial eligibility; blood-based screening (p-tau217/Aβ42 ratio)
Cutoff Values: CSF Aβ42: <800–1000 pg/mL (depending on assay) indicates amyloid pathology. Aβ42/40 ratio <0.06–0.08 (assay-dependent). Plasma Aβ42/40 ratio: <0.06 (mass spec) suggests amyloid positivity.
Reduced CSF Aβ42 reflects brain amyloid deposition (sequestered in plaques). Combined with p-tau for ATN staging. Blood-based assays (p-tau217/Aβ42 ratio) approaching CSF/PET accuracy for screening.
Alpha-Synuclein (α-Syn)
ID: BIO-008 | | Length | 695 amino acids |
| Category | Biomarker Peptides |
Structure
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (42 residues) belongs to the Biomarker Peptides class of peptides. Its structure and properties make it suitable for various research and therapeutic applications.
Applications
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (42 residues) has been studied for its potential applications in:
- Biomedical research
- Drug discovery
- Diagnostic applications
- Therapeutic development
References
- Source: biomarker-peptides.md
- Database: Wikipept Peptide Database
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