**Sequence:** Fragment of cross-linked fibrin (two D domains joined by cross-links)

Overview

Sequence: Fragment of cross-linked fibrin (two D domains joined by cross-links) is a peptide compound with applications in research and therapeutics. Sequence: 116 amino acids (precursor of calcitonin)

Chemical Identity

Property	Value
Name	Sequence: Fragment of cross-linked fibrin (two D domains joined by cross-links)
Sequence	Disease: Venous thromboembolism (VTE); disseminated intravascular coagulation (DIC); aortic dissection

Clinical Use: Rule-out VTE (DVT/PE) in low-to-moderate probability patients; DIC diagnosis; aortic dissection screening

Cutoff Values: Standard: <500 ng/mL FEU (age-adjusted: age × 10 ng/mL for patients >50 years). High sensitivity assays: <250 ng/mL for rule-out.

Fibrin degradation product. High sensitivity (~95%) but low specificity for VTE. Elevated in inflammation, malignancy, pregnancy, trauma, and elderly. Age-adjusted cutoff improves specificity in elderly.

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Sepsis / Infection Biomarkers

Procalcitonin (PCT)

ID: BIO-006 | | Length | 667 amino acids |

| Category | Biomarker Peptides |

Structure

Sequence: Fragment of cross-linked fibrin (two D domains joined by cross-links) belongs to the Biomarker Peptides class of peptides. Its structure and properties make it suitable for various research and therapeutic applications.

Applications

Sequence: Fragment of cross-linked fibrin (two D domains joined by cross-links) has been studied for its potential applications in:

• Biomedical research
• Drug discovery
• Diagnostic applications
• Therapeutic development

References

• Source: biomarker-peptides.md
• Database: Wikipept Peptide Database