**Sequence:** Large glycoprotein (~22,000 amino acids, heavily O-glycosylated)

Overview

Sequence: Large glycoprotein (~22,000 amino acids, heavily O-glycosylated) is a peptide compound with applications in research and therapeutics. Sequence: 668 amino acids (glycosylated, GPI-anchored)

Chemical Identity

Property	Value
Name	Sequence: Large glycoprotein (~22,000 amino acids, heavily O-glycosylated)
Sequence	Disease: Epithelial ovarian cancer; endometriosis; pelvic inflammatory disease; peritoneal/pleural effusions

Clinical Use: Ovarian cancer monitoring (not screening); ROMA score (with HE4); treatment response; recurrence detection; risk of malignancy index (RMI)

Cutoff Values: <35 U/mL (normal). ROMA score combines CA-125, HE4, and menopausal status for risk stratification. Elevated in endometriosis (~50%), cirrhosis, CHF, pregnancy (1st trimester).

Mucin family glycoprotein expressed on coelomic epithelium (peritoneum, pleura, pericardium, Müllerian duct derivatives). Not suitable for population screening due to low sensitivity in early-stage disease. Combined with transvaginal ultrasound for high-risk surveillance.

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CEA (Carcinoembryonic Antigen)

ID: BIO-014 | | Length | 798 amino acids |

| Category | Biomarker Peptides |

Structure

Sequence: Large glycoprotein (~22,000 amino acids, heavily O-glycosylated) belongs to the Biomarker Peptides class of peptides. Its structure and properties make it suitable for various research and therapeutic applications.

Applications

Sequence: Large glycoprotein (~22,000 amino acids, heavily O-glycosylated) has been studied for its potential applications in:

• Biomedical research
• Drug discovery
• Diagnostic applications
• Therapeutic development

References

• Source: biomarker-peptides.md
• Database: Wikipept Peptide Database