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Peptide SUMOylation Sites: Comprehensive Peptide Reference

Guide to SUMO modification of peptides in nuclear transport and transcriptional regulation. This modification affects peptide stability, receptor binding, an...

By Encyclopeptide Editorial | 1 min read
sumo post-translational modification

Overview

SUMOylation conjugates SUMO proteins (SUMO1-4) to lysine residues, primarily regulating nuclear processes.

Mechanism

The enzymatic cascade involves E1 (SAE1/SAE2), E2 (Ubc9), and E3 ligases (PIAS family, RanBP2).

Biological Significance

SUMOylation regulates transcription factor activity, DNA repair, nuclear pore function, and PML body formation. It is implicated in neurodegeneration and cancer.

References

  • Source: ENCP Peptide Database
  • Category: Peptide Modifications

Chemical Identity

PropertyValue
NamePeptide SUMOylation Sites
CategoryPeptide Modifications

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