Peptide Modifications advanced
Thioester Bonds in Peptides
Explore thioester bonds in peptide biosynthesis, including intein-mediated ligation.
By Encyclopeptide Editorial | 1 min read
thioester ligation biosynthesis modification
Overview
Thioester bonds are high-energy linkages between thiols and carboxyl groups, important in peptide biosynthesis.
Types
- Intein-mediated: Protein splicing through thioester intermediates
- NGL (Native Chemical Ligation): Cys-mediated peptide joining
- Complement C3/C4: Thioester-mediated opsonization
Biological Significance
Thioester intermediates enable native chemical ligation for synthetic protein construction. Complement thioester bonds are essential for innate immunity.
References
- Source: ENCP Peptide Database
- Category: Peptide Modifications
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