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Thioester Bonds in Peptides: Comprehensive Peptide Reference

Explore thioester bonds in peptide biosynthesis, including intein-mediated ligation. This modification affects peptide stability, receptor binding, and biolo...

By Encyclopeptide Editorial | 1 min read
thioester ligation biosynthesis modification

Overview

Thioester bonds are high-energy linkages between thiols and carboxyl groups, important in peptide biosynthesis.

Types

  • Intein-mediated: Protein splicing through thioester intermediates
  • NGL (Native Chemical Ligation): Cys-mediated peptide joining
  • Complement C3/C4: Thioester-mediated opsonization

Biological Significance

Thioester intermediates enable native chemical ligation for synthetic protein construction. Complement thioester bonds are essential for innate immunity.

References

  • Source: ENCP Peptide Database
  • Category: Peptide Modifications

Chemical Identity

PropertyValue
NameThioester Bonds in Peptides
CategoryPeptide Modifications

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