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Trabectedin Marine Alkaloid
Tetrahydroisoquinoline alkaloid from marine tunicate Ecteinascidia turbinata for soft tissue sarcoma and ovarian cancer.
By Encyclopeptide Editorial | 1 min read
trabectedin marine alkaloid sarcoma ovarian-cancer
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C39H43N3O11 |
| Molecular Weight | 761.85 g/mol |
| CAS Number | 114899-77-3 |
| Product Name | Yondelis |
| Source | Ecteinascidia turbinata (marine tunicate) |
Structure
Trabectedin is a tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, forming adducts that interfere with DNA repair mechanisms and transcription.
Mechanism of Action
- Binds DNA minor groove (N2 of guanine)
- Forms DNA adducts
- Recruits nucleotide excision repair (NER)
- Disrupts transcription-coupled NER
- Induces apoptosis
Clinical Applications
- Soft tissue sarcoma (advanced, liposarcoma)
- Relapsed platinum-sensitive ovarian cancer
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