Therapeutic Peptides Expanded 2 intermediate
Trastuzumab Deruxtecan: Oligopeptide Research Reference
Trastuzumab Deruxtecan, a bioactive peptide compound with documented applications in biomedical research, pharmacological studies, and therapeutic development
By Encyclopeptide Editorial | 1 min read
therapeutic-peptides-expanded-2 peptide oligopeptide
Overview
Trastuzumab Deruxtecan is a bioactive peptide with well-characterized properties and therapeutic applications.
Structure
| Property | Value |
|---|---|
| Name | Trastuzumab Deruxtecan |
| Sequence | Anti-HER2 monoclonal antibody conjugated to topoisomerase I inhibitor payload (deruxtecan) via cleavable linker; DAR ~8 |
| Length | ~1327 amino acids (antibody) + linker-payload |
| Molecular Weight | ~153 kDa (antibody-drug conjugate) |
| Category | Oncology / Antibody-Drug Conjugate |
Mechanism of Action
Antibody-drug conjugate; anti-HER2 antibody delivers deruxtecan (topoisomerase I inhibitor) to HER2-expressing cells, causing DNA damage and cell death. Bystander effect kills adjacent tumor cells
References
- Wikipept Peptide Database
- Primary literature (see individual entries)
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